Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TOP1 | P11387 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865971 | 0.91 | MCHR1 (0.35) | MCHR1KDM4ESMN1; SMN2TOP1 | |
| SCHEMBL9603121 | 0.86 | CDK4 (0.40) | ALDH1A1 | |
| SCHEMBL9602772 | 0.84 | MCHR1 (0.35) | MCHR1KDM4EALDH1A1TOP1 | |
| SCHEMBL10561556 | 0.84 | KMT2A (0.40) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL9866640 | 0.82 | MCHR1 (0.34) | MCHR1 | |
| SCHEMBL9865991 | 0.80 | CDK4 (0.31) | KDM4ESMN1; SMN2 | |
| SCHEMBL9602777 | 0.80 | MCHR1 (0.35) | MCHR1TOP1 | |
| SCHEMBL10562795 | 0.79 | GRM5 (0.37) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL10560169 | 0.79 | KDM4E (0.37) | KDM4ESMN1; SMN2 | |
| Fumaric Acid SCHEMBL9867501 | 0.79 | ALDH1A1 (0.35) | MCHR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |