Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602906 | 0.91 | MCHR1 (0.35) | MCHR1KDM4ESMN1; SMN2TOP1 | |
| SCHEMBL9865991 | 0.88 | CDK4 (0.31) | KDM4ESMN1; SMN2MAPTTP53 | |
| SCHEMBL10564407 | 0.83 | APP (0.43) | KDM4ESMN1; SMN2MAPTTP53LMNA | |
| SCHEMBL9602777 | 0.81 | MCHR1 (0.35) | MCHR1TOP1 | |
| SCHEMBL9864982 | 0.79 | KDM4E (0.40) | KDM4ESMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL10558711 | 0.79 | MAPT (0.43) | KDM4ESMN1; SMN2MAPTTP53LMNA | |
| SCHEMBL9866052 | 0.78 | MCHR1 (0.34) | MCHR1KDM4ESMN1; SMN2MAPTTOP1 | |
| SCHEMBL9868430 | 0.78 | TOP1 (0.35) | MCHR1TOP1TP53HTT | |
| SCHEMBL9603121 | 0.77 | CDK4 (0.40) | HTT | |
| SCHEMBL9602794 | 0.77 | CHRM2 (0.32) | SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |