Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.74 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597381 | 0.89 | ALOX5 (0.80) | ALOX5BRD4ALDH1A1KDM4EUSP2 | |
| SCHEMBL9596075 | 0.85 | ALOX5 (1.00) | ALOX5ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL9596561 | 0.77 | ALOX5 (0.64) | ALOX5BRD4ALDH1A1KDM4EBRD2 | |
| SCHEMBL9596545 | 0.72 | ALOX5 (1.00) | ALOX5KDM4EPKMMAPK10 | |
| SCHEMBL9646981 | 0.68 | ALOX5 (0.66) | ALOX5ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL9597144 | 0.66 | ALOX5 (0.75) | ALOX5BRD4KDM4EKMT2ATSHR | |
| SCHEMBL9646389 | 0.65 | ALOX5 (0.70) | ALOX5MEN1KMT2APKMMAPK10 | |
| SCHEMBL9646305 | 0.65 | ALOX5 (0.70) | ALOX5KDM4EMEN1KMT2APKM | |
| SCHEMBL9646889 | 0.64 | NOX4 (0.49) | ALOX5ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL31456668 | 0.64 | MET (0.46) | BRD4ALDH1A1KDM4EBRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229408-A | 4-carbamoyl-1,2-dihydro-3H-indazol-3-one derivatives | ICI PHARMA (GB) | 1993-07-20 | — | — | US | disclosed |
| US-5036083-A | Antiallergens, antiflammatory | ICI PHARMA (FR) | 1991-07-30 | — | — | US | disclosed |