Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | LIPE | Q05469 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13499905 | 0.71 | CCNE1 (0.65) | TDP1CCNE1CDK2CDK5RAB9A | |
| SCHEMBL10871503 | 0.68 | L3MBTL1 (0.70) | ATMTDP1L3MBTL1LIPERAB9A | |
| SCHEMBL29937801 | 0.66 | L3MBTL1 (0.44) | ATMTDP1L3MBTL1LIPERAB9A | |
| SCHEMBL6687991 | 0.65 | L3MBTL1 (0.66) | ATMTDP1L3MBTL1LIPERAB9A | |
| SCHEMBL12475977 | 0.64 | MLYCD (0.51) | CCNE1CDK2CDK5SMN1; SMN2NPC1 | |
| SCHEMBL12420813 | 0.64 | L3MBTL1 (0.45) | ATMTDP1L3MBTL1LIPERAB9A | |
| SCHEMBL1444774 | 0.64 | TDP1 (0.63) | ATMTDP1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL9061345 | 0.63 | TDP1 (0.47) | ATMTDP1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL149840 | 0.63 | SMN1; SMN2 (0.34) | CCNE1CDK2CDK5RAB9ASMN1; SMN2 | |
| SCHEMBL1428351 | 0.63 | USP30 (0.37) | CCNE1CDK2CDK5RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868030-B2 | FBPase inhibitors for diabetes | HOFFMANN-LA ROCHE INC. (US) | 2011-01-11 | — | — | US | disclosed |