Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 13/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9606797 | 0.89 | CTSK (0.41) | GSK3BDYRK1AABL1AAK1 | |
| SCHEMBL210240 | 0.87 | GSK3B (0.39) | GSK3BDYRK1AABL1MAPK1AAK1 | |
| SCHEMBL210239 | 0.87 | GSK3B (0.39) | GSK3BDYRK1AABL1MAPK1AAK1 | |
| SCHEMBL2726539 | 0.85 | SYK (0.39) | GSK3BDYRK1AABL1MAPK1 | |
| SCHEMBL210058 | 0.85 | SYK (0.39) | GSK3BDYRK1AABL1MAPK1 | |
| SCHEMBL211279 | 0.84 | GSK3B (0.40) | GSK3BDYRK1AABL1WNT1TTK | |
| SCHEMBL211280 | 0.84 | GSK3B (0.40) | GSK3BDYRK1AABL1WNT1TTK | |
| SCHEMBL2840471 | 0.77 | ABL1 (0.40) | GSK3BDYRK1AABL1AAK1WNT1 | |
| SCHEMBL2724403 | 0.76 | GSK3B (0.36) | GSK3BDYRK1AABL1 | |
| SCHEMBL212094 | 0.76 | CTSK (0.41) | GSK3BDYRK1AABL1AAK1WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895582-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2014-11-25 | — | — | US | disclosed |
| US-8759374-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-20130053348-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | QIAN XIANGPING (US) | 2013-02-28 | — | — | US | disclosed |
| US-20120135964-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | QIAN XIANGPING (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135964-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | MYLK, MYH2, MYH10 | GSK3B 776/4885DYRK1A 4356/4885ABL1 956/4885 |
| US-20130053348-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | MYLK, MYH2, MYH10 | GSK3B 776/4885DYRK1A 4356/4885ABL1 956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.