Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2294571 | 0.92 | MMP8 (0.41) | MMP8KDM4EGAAALDH1A1GLA | |
| SCHEMBL12011133 | 0.88 | GAA (0.38) | MMP8KDM4EGAAALDH1A1GLA | |
| SCHEMBL4611439 | 0.81 | HDAC1 (0.44) | PTGS2AKR1C3AKR1C2PTGS1HPGD | |
| SCHEMBL12403212 | 0.81 | PTGS2 (0.38) | PTGS2PTGS1KDM4EGAAALDH1A1 | |
| SCHEMBL3676379 | 0.78 | MMP8 (0.42) | MMP8PTGS2CA12CA1CA2 | |
| SCHEMBL8475858 | 0.76 | LMNA (0.51) | MMP8KDM4EGAAALDH1A1TSHR | |
| SCHEMBL2297081 | 0.75 | MMP8 (0.41) | MMP8PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL20703549 | 0.74 | TDP1 (0.42) | MMP8AKR1C3AKR1C2ALDH1A1TSHR | |
| SCHEMBL2299568 | 0.73 | AKR1C3 (0.52) | AKR1C3AKR1C2PTGS1HDAC1HDAC6 | |
| SCHEMBL12012637 | 0.73 | MMP8 (0.39) | MMP8PTGS2GAAALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457897-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-05-30 | — | — | EP | disclosed |