Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 9/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322039 | 0.90 | TRPV4 (0.44) | TRPV3SMN1; SMN2KCNH2 | |
| SCHEMBL27902107 | 0.81 | HPGDS (0.57) | NPC1SMN1; SMN2RXFP1KCNH2 | |
| SCHEMBL9607344 | 0.78 | RXFP1 (0.50) | NPC1RAB9ASMN1; SMN2RXFP1TP53 | |
| SCHEMBL1474603 | 0.76 | MAPT (0.42) | NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL29446527 | 0.75 | TRPV4 (0.42) | TRPV3KCNH2 | |
| SCHEMBL9607405 | 0.74 | RXFP1 (0.71) | NPC1RAB9ASMN1; SMN2RXFP1TP53 | |
| SCHEMBL8515947 | 0.74 | SMN1; SMN2 (0.56) | TRPV3NPC1RAB9ASMN1; SMN2KCNH2 | |
| SCHEMBL25212518 | 0.74 | TRPV4 (0.44) | TRPV3DGAT1KCNH2 | |
| SCHEMBL22817600 | 0.74 | GSK3B (0.44) | TP53 | |
| SCHEMBL17873467 | 0.74 | GSK3B (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |