Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9607167 | 0.80 | PDE2A (0.48) | PDE2ASLC6A4HRH3TSHREPHX2 | |
| SCHEMBL8534436 | 0.79 | SLC6A4 (0.42) | PDE2ASLC6A4HRH3CETPEPHX1 | |
| SCHEMBL8514972 | 0.75 | SLC6A4 (0.46) | PDE2ASLC6A4TSHRCYP11B1CYP11B2 | |
| SCHEMBL9607481 | 0.74 | PDE2A (0.53) | PDE2APTGS1PTGS2 | |
| SCHEMBL9607399 | 0.74 | BCL2L1 (0.41) | PDE2ASLC6A4HRH3TSHREPHX2 | |
| SCHEMBL31287447 | 0.73 | PDE2A (0.51) | PDE2ACETP | |
| SCHEMBL2092054 | 0.72 | SLC6A4 (0.56) | SLC6A4TSHREPHX2L3MBTL1CYP11B1 | |
| SCHEMBL4542016 | 0.72 | PDE2A (0.54) | PDE2AHRH3TSHRL3MBTL1 | |
| SCHEMBL9607166 | 0.71 | DAO (0.42) | SLC6A4TSHRCYP11B1CYP11B2SLC5A1 | |
| SCHEMBL20115909 | 0.70 | GRM2 (0.49) | SLC6A4PPARACYP11B1CYP11B2SLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |