Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 12/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.35 |
| ▸ | TSHR | P16473 | 7/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 4/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9608219 | 0.87 | PTGDR2 (0.34) | CYP3A4CYP2C19CYP1A2CYP2D6TSHR | |
| SCHEMBL9608220 | 0.87 | RAB9A (0.43) | CYP3A4CYP2C19CYP1A2CYP2D6TSHR | |
| SCHEMBL12960838 | 0.86 | CYP3A4 (0.34) | CYP3A4CYP2C19CYP1A2CYP2D6TSHR | |
| SCHEMBL9608222 | 0.82 | CA1 (0.38) | CYP3A4CYP2C19CYP1A2CYP2D6TSHR | |
| SCHEMBL8484011 | 0.81 | AURKA (0.43) | CYP3A4CYP2C19CYP1A2CYP2D6TSHR | |
| SCHEMBL9608208 | 0.80 | CHRNB2 (0.41) | POLBGALR3CHRNB2CHRNA4 | |
| SCHEMBL8506746 | 0.80 | CYP1A2 (0.36) | CYP3A4CYP2C19CYP1A2CYP2D6TSHR | |
| SCHEMBL9608010 | 0.80 | HTT (0.48) | CYP3A4CYP2C19CYP1A2CYP2D6TSHR | |
| SCHEMBL9608215 | 0.79 | KMT2A (0.36) | CYP3A4CYP2C19CYP1A2CYP2D6TSHR | |
| SCHEMBL9608175 | 0.79 | CYP1A2 (0.52) | CYP3A4CYP2C19CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9089139-B2 | Agri-horticultural pest control compositions comprising 4-(3-butynyl)aminopyrimidine derivatives | SDS BIOTECH K. K. (JP) | 2015-07-28 | — | — | US | disclosed |
| US-9089139-B2 | Agri-horticultural pest control compositions comprising 4-(3-butynyl)aminopyrimidine derivatives | SDS BIOTECH K. K. (JP) | 2015-07-28 | — | — | US | disclosed |
| US-8586505-B2 | 4-(3-butynyl)aminopyrimidine derivatives as pest control agents for agricultural and horticultural use | SDS BIOTECH K. K. (JP) | 2013-11-19 | — | — | US | disclosed |
| US-20130296271-A1 | Agri-Horticultural Pest Control Compositions Comprising 4-(3-Butynyl)Aminopyrimidine Derivatives | SDS BIOTECH K.K. (JP) | 2013-11-07 | — | — | US | disclosed |
| US-20130296271-A1 | Agri-Horticultural Pest Control Compositions Comprising 4-(3-Butynyl)Aminopyrimidine Derivatives | SDS BIOTECH K.K. (JP) | 2013-11-07 | — | — | US | disclosed |
| US-20120136150-A1 | 4-(3-Butynyl)Aminopyrimidine Derivatives as Pest Control Agents for Agricultural and Horticultural Use | SDS BIOTECH K.K. (JP) | 2012-05-31 | — | — | US | disclosed |
| WO-2011007839-A1 | 4-(3-BUTYNYL)AMINOPYRIMIDINE DERIVATIVES AS PEST CONTROL AGENTS FOR AGRICULTURAL AND HORTICULTURAL USE | 株式会社エス・ディー・エス バイオテック (JP) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296271-A1 | Agri-Horticultural Pest Control Compositions Comprising 4-(3-Butynyl)Aminopyrimidine Derivatives | HCN1, HCN2, HCN3 | CYP3A4 1631/4885CYP2C19 2313/4885CYP1A2 2322/4885 |
| US-20120136150-A1 | 4-(3-Butynyl)Aminopyrimidine Derivatives as Pest Control Agents for Agricultural and Horticultural Use | CBR3, CBR1, HRH2 | CYP3A4 823/4885CYP2C19 1497/4885CYP1A2 169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.