SCHEMBL9608856

SCHEMBL9608856

NC/C=C/C=C/CCc1cccnc1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.58
CYP2A6 P11509 1/20 0.54
HRH1 P35367 2/20 0.51
TDP1 Q9NUW8 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
GPR52 Q9Y2T5 1/20 0.44
CYP1A2 P05177 2/20 0.42
CYP2D6 P10635 2/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
HRH4 Q9H3N8 2/20 0.41
HRH3 Q9Y5N1 2/20 0.41
TBXAS1 P24557 1/20 0.41
PLAU P00749 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8514456 0.83 CHRNA7 (0.49) CHRNA7CYP2A6HRH1TDP1L3MBTL1
SCHEMBL8511440 0.83 CHRNA7 (0.49) CHRNA7CYP2A6HRH1TDP1L3MBTL1
SCHEMBL9608746 0.81 CHRNA7 (0.50) CHRNA7CYP2A6HRH1TDP1L3MBTL1
SCHEMBL8512647 0.78 GPR52 (0.57) CHRNA7GPR52TBXAS1
SCHEMBL8512649 0.78 GPR52 (0.57) CHRNA7GPR52TBXAS1
SCHEMBL15547026 0.78 HTR2A (0.48) CYP2A6GPR52CYP1A2CYP2D6
SCHEMBL15547029 0.78 HTR2A (0.48) CYP2A6GPR52CYP1A2CYP2D6
SCHEMBL868537 0.77 CHRNA7 (0.57) CHRNA7CYP2A6HRH1TDP1L3MBTL1
SCHEMBL9608492 0.76 CHRNA7 (0.52) CHRNA7CYP2A6HRH1TDP1L3MBTL1
Bromide SCHEMBL17353587 0.75 CHRNA7 (0.55) CHRNA7CYP2A6HRH1TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012069605-A1 NOVEL E,E-DIENE COMPOUNDS AND THEIR USE AS MEDICAMENTS AND COSMETICS DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL (DE) 2012-05-31 WO disclosed