Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8511902 | 0.88 | PTGDR2 (0.57) | P2RX7PTGDR2TSHR | |
| SCHEMBL9609041 | 0.83 | F2 (0.47) | P2RX7PTGDR2F2 | |
| SCHEMBL8516281 | 0.78 | L3MBTL1 (0.53) | P2RX7PTGDR2TSHR | |
| SCHEMBL9609107 | 0.77 | P2RX7 (0.47) | P2RX7PTGDR2TSHR | |
| SCHEMBL9609110 | 0.76 | PTGDR2 (0.79) | P2RX7PTGDR2TSHR | |
| SCHEMBL9882891 | 0.76 | AR (0.48) | P2RX7PTGDR2TSHR | |
| SCHEMBL9609102 | 0.73 | PDE4B (0.59) | P2RX7TSHR | |
| SCHEMBL8513084 | 0.71 | PTGDR2 (0.55) | P2RX7PTGDR2 | |
| SCHEMBL11255334 | 0.70 | TSHR (0.76) | P2RX7TSHR | |
| SCHEMBL23013058 | 0.69 | SLC34A1 (0.55) | P2RX7TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069175-A1 | NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR | ALMIRALL, S.A. (ES) | 2012-05-31 | — | — | WO | disclosed |
| EP-2457900-A1 | New pyrazole derivatives having CRTh2 antagonistic behaviour | Almirall, S.A. (ES) | 2012-05-30 | — | — | EP | disclosed |