Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.79 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510947 | 0.89 | PTGDR2 (1.00) | PTGDR2P2RX7SMN1; SMN2LMNANAMPT | |
| SCHEMBL8510948 | 0.89 | PTGDR2 (1.00) | PTGDR2P2RX7SMN1; SMN2LMNANAMPT | |
| SCHEMBL9608949 | 0.76 | P2RX7 (0.46) | PTGDR2P2RX7TSHR | |
| SCHEMBL8516281 | 0.75 | L3MBTL1 (0.53) | PTGDR2P2RX7ALDH1A1GAATSHR | |
| SCHEMBL9609107 | 0.74 | P2RX7 (0.47) | PTGDR2P2RX7TSHRNPC1RAB9A | |
| SCHEMBL9882891 | 0.73 | AR (0.48) | PTGDR2P2RX7TSHRNPC1RAB9A | |
| SCHEMBL9609041 | 0.73 | F2 (0.47) | PTGDR2P2RX7ALDH1A1GAAHTT | |
| SCHEMBL9609102 | 0.71 | PDE4B (0.59) | P2RX7SMN1; SMN2ALDH1A1TSHRNPC1 | |
| SCHEMBL11255334 | 0.68 | TSHR (0.76) | P2RX7TSHRNPC1RAB9A | |
| SCHEMBL8511496 | 0.67 | PTGDR2 (0.63) | PTGDR2P2RX7LMNAALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069175-A1 | NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR | ALMIRALL, S.A. (ES) | 2012-05-31 | — | — | WO | disclosed |
| EP-2457900-A1 | New pyrazole derivatives having CRTh2 antagonistic behaviour | Almirall, S.A. (ES) | 2012-05-30 | — | — | EP | disclosed |