Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL508531 | 0.85 | P2RX7 (0.43) | LMNAMEN1KMT2APDE4DAR | |
| SCHEMBL9609104 | 0.77 | RAB9A (0.43) | KDM4EALDH1A1HSD17B10LMNAMEN1 | |
| SCHEMBL9609113 | 0.75 | BRD4 (0.46) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL508365 | 0.75 | JAK2 (0.37) | KDM4EALDH1A1HPGDHSD17B10BRD4 | |
| SCHEMBL508150 | 0.72 | HCAR2 (0.38) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL508945 | 0.70 | P2RX7 (0.31) | KDM4ELMNAP2RX7MTNR1AMTNR1B | |
| SCHEMBL508354 | 0.69 | P2RX7 (0.43) | KDM4EALDH1A1LMNAP2RX7MTNR1A | |
| SCHEMBL508223 | 0.68 | P2RX7 (0.44) | KDM4ELMNAP2RX7 | |
| SCHEMBL509202 | 0.67 | MTNR1A (0.42) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL2459897 | 0.66 | MTNR1A (0.43) | LMNAMTNR1AMTNR1BNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069175-A1 | NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR | ALMIRALL, S.A. (ES) | 2012-05-31 | — | — | WO | disclosed |
| EP-2457900-A1 | New pyrazole derivatives having CRTh2 antagonistic behaviour | Almirall, S.A. (ES) | 2012-05-30 | — | — | EP | disclosed |