Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GYS1 | P13807 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9609104 | 0.87 | RAB9A (0.43) | RAB9AMAPK1ALOX15LMNATP53 | |
| SCHEMBL508531 | 0.76 | P2RX7 (0.43) | P2RX7LMNAMEN1KMT2A | |
| SCHEMBL9608998 | 0.75 | KDM4E (0.35) | BRD4P2RX7MAPK1HPGDLMNA | |
| SCHEMBL17055629 | 0.74 | IKBKB (0.47) | P2RX7RAB9AGYS1ALOX12MAPK1 | |
| SCHEMBL2427540 | 0.71 | MAPT (0.56) | RAB9AGAALMNAMAPTCYP1A2 | |
| SCHEMBL8515102 | 0.69 | RAB9A (0.49) | RAB9AGAALMNAMAPTKDM4E | |
| SCHEMBL27499014 | 0.69 | MAP2K4 (0.48) | GYS1ALOX12MAPK1GAAALOX15 | |
| SCHEMBL28320367 | 0.69 | NR1H2 (0.54) | RAB9AGAAHPGDLMNAMAPT | |
| SCHEMBL7510671 | 0.68 | IKBKB (0.47) | GYS1ALOX12MAPK1GAAALOX15 | |
| SCHEMBL509202 | 0.68 | MTNR1A (0.42) | P2RX7MAPK1GAAHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069175-A1 | NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR | ALMIRALL, S.A. (ES) | 2012-05-31 | — | — | WO | disclosed |
| EP-2457900-A1 | New pyrazole derivatives having CRTh2 antagonistic behaviour | Almirall, S.A. (ES) | 2012-05-30 | — | — | EP | disclosed |