Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20563545 | 0.84 | GALR3 (0.55) | HTR7MAPK1HTTLMNACYP1A2 | |
| SCHEMBL21593125 | 0.84 | CYP1A2 (0.51) | HTR7CYP1A2CYP3A4CYP2D6ALOX15 | |
| SCHEMBL20564558 | 0.84 | CCNC (0.47) | HTR7HTTCCNCCDK8MKNK1 | |
| SCHEMBL1666072 | 0.83 | CYP1A2 (0.64) | MAPK1CYP1A2CYP3A4CYP2D6ALOX15 | |
| SCHEMBL29836457 | 0.83 | CYP1A2 (0.64) | MAPK1CYP1A2CYP3A4CYP2D6ALOX15 | |
| SCHEMBL28023199 | 0.82 | CNR1 (0.53) | HTR7CNR1CNR2SMN1; SMN2 | |
| SCHEMBL23291892 | 0.81 | CCNC (0.46) | HTR7HTTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL20562824 | 0.81 | ABL1 (0.42) | HTR7HTTCCNCCDK8MKNK2 | |
| SCHEMBL16343362 | 0.81 | HTR7 (0.62) | HTR7MAPK1HTTAPPEGFR | |
| SCHEMBL20563447 | 0.79 | HTR7 (0.41) | HTR7MAPK1HTTLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253568-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-08-19 | — | — | US | disclosed |
| WO-2019238628-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-12-19 | — | — | WO | disclosed |
| EP-2832733-B1 | 4-ALKANOYLAMINO-3-PYRAZOLONE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2018-08-29 | — | — | EP | disclosed |
| US-9212170-B2 | 4-alkanoylamino-3-pyrazolone derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-12-15 | — | — | US | disclosed |
| EP-2832733-A1 | 4-ALKANOYLAMINO-3-PYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-02-04 | — | — | EP | disclosed |
| CN-104321318-A | 4-alkanoylamino-3-pyrazolone derivative | DAIICHI SANKYO CO LTD | 2015-01-28 | — | — | CN | disclosed |
| US-20150011552-A1 | 4-ALKANOYLAMINO-3-PYRAZOLONE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-01-08 | — | — | US | disclosed |
| US-20120136150-A1 | 4-(3-Butynyl)Aminopyrimidine Derivatives as Pest Control Agents for Agricultural and Horticultural Use | SDS BIOTECH K.K. (JP) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011552-A1 | 4-ALKANOYLAMINO-3-PYRAZOLONE DERIVATIVE | EPOR, EGLN2, EGLN3 | HTR7 2851/4885MAPK1 3413/4885HTT 1121/4885 |
| US-20120136150-A1 | 4-(3-Butynyl)Aminopyrimidine Derivatives as Pest Control Agents for Agricultural and Horticultural Use | CBR3, CBR1, HRH2 | HTR7 1613/4885MAPK1 4076/4885HTT 2572/4885 |
| US-20210253568-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | ROCK1, ROCK2, RHOA | HTR7 1771/4885MAPK1 393/4885HTT 4795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.