SCHEMBL9610041

SCHEMBL9610041

N#Cc1ccc(C#Cc2ccc(C#Cc3ccc(C#N)c(C#N)c3)cc2)cc1C#N

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.41
MAOA P21397 8/20 0.41
KDM4E B2RXH2 1/20 0.41
USP2 O75604 1/20 0.41
ALDH1A1 P00352 1/20 0.41
FFAR1 O14842 1/20 0.41
PTPN1 P18031 1/20 0.38
PTPN6 P29350 1/20 0.38
PTPN11 Q06124 1/20 0.38
ACACB O00763 1/20 0.37
IMPDH2 P12268 1/20 0.36
IMPDH1 P20839 1/20 0.36
APP P05067 1/20 0.36
TRPV4 Q9HBA0 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL818327 0.84 IMPDH2 (0.45) MAOBMAOAKDM4EUSP2ALDH1A1
SCHEMBL30488974 0.84 IMPDH2 (0.45) MAOBMAOAKDM4EUSP2ALDH1A1
SCHEMBL9612005 0.79 TRPV4 (0.55) TRPV4
SCHEMBL16956449 0.78 MAOB (0.39) MAOBMAOAKDM4EUSP2ALDH1A1
SCHEMBL4394514 0.78 MAOB (0.39) MAOBMAOAKDM4EUSP2ALDH1A1
SCHEMBL26392151 0.74 ALDH1A1 (0.50) ALDH1A1FFAR1
SCHEMBL8386004 0.73 MAPT (0.55) KDM4EALDH1A1FFAR1PTPN1PTPN11
SCHEMBL22225479 0.73 TRPV4 (0.48) FFAR1APPTRPV4
SCHEMBL2094284 0.73 ALDH1A1 (0.63) MAOBMAOAKDM4EUSP2ALDH1A1
SCHEMBL9293782 0.72 CYP11B1 (0.50) ALDH1A1FFAR1TRPV4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9169208-B2 Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties E I DU PONT DE NEMOURS AND COMPANY (US) 2015-10-27 US disclosed
US-9169208-B2 Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties E I DU PONT DE NEMOURS AND COMPANY (US) 2015-10-27 US disclosed
US-20120135249-A1 AROMATIC AND AROMATIC/HETEROAROMATIC MOLECULAR STRUCTURES WITH CONTROLLABLE ELECTRON CONDUCTING PROPERTIES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2012-05-31 US disclosed
US-20120135249-A1 AROMATIC AND AROMATIC/HETEROAROMATIC MOLECULAR STRUCTURES WITH CONTROLLABLE ELECTRON CONDUCTING PROPERTIES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2012-05-31 US disclosed
US-20110024691-A1 AROMATIC AND AROMATIC/HETEROAROMATIC MOLECULAR STRUCTURES WITH CONTROLLABLE ELECTRON CONDUCTING PROPERTIES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-02-03 US disclosed
US-20110024691-A1 AROMATIC AND AROMATIC/HETEROAROMATIC MOLECULAR STRUCTURES WITH CONTROLLABLE ELECTRON CONDUCTING PROPERTIES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-02-03 US disclosed
US-7638632-B2 4-Ethynyl (1,2-dicyanobenzene)-4'-Ethynylphenyl-1(4,5-dicyanobenzene); 1,4-Bis(4-pyridyl)butadiyne; 4-ethynyl(pyridine)-4'-ethynylnaphthalene-1-pyridine; self-assembled mono-, multilayers/ supramolecular objects; three-terminal devices; logic switches;nanoelectronic ; computers; wires; dielectrics E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-12-29 US disclosed
US-20090270627-A1 AROMATIC AND AROMATIC/HETEROAROMATIC MOLECULAR STRUCTURES WITH CONTROLLABLE ELECTRON CONDUCTING PROPERTIES FRENCH ROGER HARQUAIL 2009-10-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120135249-A1 AROMATIC AND AROMATIC/HETEROAROMATIC MOLECULAR STRUCTURES WITH CONTROLLABLE ELECTRON CONDUCTING PROPERTIES AHR, TYR, ARNT MAOB 165/4885MAOA 47/4885KDM4E 1887/4885
US-20110024691-A1 AROMATIC AND AROMATIC/HETEROAROMATIC MOLECULAR STRUCTURES WITH CONTROLLABLE ELECTRON CONDUCTING PROPERTIES AHR, TYR, ARNT MAOB 165/4885MAOA 47/4885KDM4E 1887/4885
US-20090270627-A1 AROMATIC AND AROMATIC/HETEROAROMATIC MOLECULAR STRUCTURES WITH CONTROLLABLE ELECTRON CONDUCTING PROPERTIES AHR, TYR, ARNT MAOB 165/4885MAOA 47/4885KDM4E 1887/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.