Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9610847 | 0.91 | SRC (0.49) | HDAC1HDAC7HDAC8HDAC6HDAC3 | |
| SCHEMBL9791549 | 0.86 | CA1 (0.57) | HDAC1HDAC7HDAC8HDAC6HDAC3 | |
| SCHEMBL30249175 | 0.81 | HDAC1 (0.53) | HDAC1HDAC7HDAC8HDAC6HDAC3 | |
| SCHEMBL30249298 | 0.80 | HDAC1 (0.70) | HDAC1HDAC7HDAC8HDAC6HDAC3 | |
| SCHEMBL17845228 | 0.80 | EPHX2 (0.55) | HDAC1HDAC7HDAC8HDAC6HDAC3 | |
| SCHEMBL9610848 | 0.79 | DGAT1 (0.46) | HDAC1HDAC7HDAC8HDAC6HDAC3 | |
| SCHEMBL20870490 | 0.78 | SRC (0.51) | HDAC1HDAC7HDAC8HDAC6HDAC3 | |
| SCHEMBL13661999 | 0.75 | L3MBTL1 (0.73) | HDAC1HDAC7HDAC8HDAC6HDAC3 | |
| SCHEMBL2023219 | 0.74 | SRC (0.63) | HDAC1HDAC7HDAC8HDAC6HDAC3 | |
| SCHEMBL6929655 | 0.74 | KMT2A (0.56) | HDAC1HDAC7HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651411-B1 | METHODS AND COMPOSITIONS FOR IMPROVED F-18 LABELING OF PROTEINS, PEPTIDES AND OTHER MOLECULES | IMMUNOMEDICS INC (US) | 2020-09-16 | — | — | EP | disclosed |
| US-9399077-B2 | Metallocene compounds and labeled molecules comprising the same for in vivo imaging | APTENIA S.R.L. (IT) | 2016-07-26 | — | — | US | disclosed |
| US-9399077-B2 | Metallocene compounds and labeled molecules comprising the same for in vivo imaging | APTENIA S.R.L. (IT) | 2016-07-26 | — | — | US | disclosed |
| US-20160008495-A1 | Metallocene Compounds and Labeled Molecules Comprising the Same for In Vivo Imaging | APTENIA S.R.L. (IT) | 2016-01-14 | — | — | US | disclosed |
| US-20160008495-A1 | Metallocene Compounds and Labeled Molecules Comprising the Same for In Vivo Imaging | APTENIA S.R.L. (IT) | 2016-01-14 | — | — | US | disclosed |
| US-9028800-B2 | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules | IMMUNOMEDICS, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-9028800-B2 | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules | IMMUNOMEDICS, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20140377177-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | IMMUNOMEDICS, INC. | 2014-12-25 | — | — | US | disclosed |
| US-20140377177-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | IMMUNOMEDICS, INC. | 2014-12-25 | — | — | US | disclosed |
| US-8758726-B2 | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules | IMMUNOMEDICS, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-8758726-B2 | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules | IMMUNOMEDICS, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-20140017168-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | IMMUNOMEDICS, INC. (US) | 2014-01-16 | — | — | US | disclosed |
| US-20140017168-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | IMMUNOMEDICS, INC. (US) | 2014-01-16 | — | — | US | disclosed |
| US-8545809-B2 | Methods and compositions for improved 18F labeling of proteins, peptides and other molecules | IMMUNOMEDICS, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-8545809-B2 | Methods and compositions for improved 18F labeling of proteins, peptides and other molecules | IMMUNOMEDICS, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| WO-2012082618-A2 | METHODS AND COMPOSITIONS FOR IMPROVED F-18 LABELING OF PROTEINS, PEPTIDES AND OTHER MOLECULES | IMMUNOMEDICS, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-20120134920-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | IMMUNOMEDICS, INC. (US) | 2012-05-31 | — | — | US | disclosed |
| US-20120134920-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | IMMUNOMEDICS, INC. (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120134920-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | F13B, FCGRT, PAICS | HDAC1 4059/4885HDAC7 4762/4885HDAC8 3925/4885 |
| US-20160008495-A1 | Metallocene Compounds and Labeled Molecules Comprising the Same for In Vivo Imaging | MEN1, MPI, TFRC | HDAC1 2248/4885HDAC7 4351/4885HDAC8 4567/4885 |
| US-20140017168-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | F13B, FCGRT, PAICS | HDAC1 4059/4885HDAC7 4762/4885HDAC8 3925/4885 |
| US-20140377177-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | F13B, FCGRT, PAICS | HDAC1 4059/4885HDAC7 4762/4885HDAC8 3925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.