Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 8/20 | 1.00 |
| ▸ | CACNA1B | Q00975 | 1/20 | 1.00 |
| ▸ | APBA1 | Q02410 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.83 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.83 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.83 |
| ▸ | PPIA | P62937 | 1/20 | 0.83 |
| ▸ | PPID | Q08752 | 1/20 | 0.83 |
| ▸ | MEN1 | O00255 | 7/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.82 |
| ▸ | MAPT | P10636 | 6/20 | 0.82 |
| ▸ | HPGD | P15428 | 5/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.82 |
| ▸ | POLB | P06746 | 4/20 | 0.82 |
| ▸ | BLM | P54132 | 4/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.82 |
| ▸ | CASP1 | P29466 | 4/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613308 | 0.91 | TDP1 (1.00) | PTPN7CACNA1BAPBA1TDP1HSPD1 | |
| SCHEMBL13856682 | 0.90 | PTPN7 (1.00) | PTPN7CACNA1BAPBA1TDP1HSPD1 | |
| SCHEMBL9613352 | 0.81 | PTPN7 (0.73) | PTPN7CACNA1BAPBA1TDP1HSPD1 | |
| SCHEMBL2116513 | 0.80 | PTPN7 (1.00) | PTPN7CACNA1BAPBA1TDP1HSPD1 | |
| SCHEMBL9613359 | 0.78 | PTPN7 (0.77) | PTPN7CACNA1BAPBA1TDP1HSPD1 | |
| SCHEMBL5997551 | 0.77 | KDM4D (0.98) | PTPN7CACNA1BAPBA1TDP1HSPD1 | |
| SCHEMBL5992705 | 0.76 | KDM4D (1.00) | PTPN7CACNA1BAPBA1TDP1HSPD1 | |
| SCHEMBL6238251 | 0.76 | PTPN7 (1.00) | PTPN7CACNA1BAPBA1TDP1HSPD1 | |
| SCHEMBL9613330 | 0.75 | TDP1 (0.62) | PTPN7CACNA1BAPBA1TDP1HSPD1 | |
| SCHEMBL9613384 | 0.74 | IKBKB (1.00) | PTPN7CACNA1BAPBA1TDP1HSPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140050728-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CYCLOPHILIN D FOR THE TREATMENT AND PREVENTION OF OBESITY AND KIDNEY INDICATIONS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2014-02-20 | — | — | US | claimed |
| WO-2012103520-A1 | METHODS AND COMPOSITIONS FOR MODULATING CYCLOPHILIN D | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-08-02 | — | — | WO | claimed |
| WO-2016172545-A1 | CASTRATION-RESISTANT PROSTATE CANCER | NUTECH VENTURES (US) | 2016-10-27 | — | — | WO | disclosed |
| US-20160310528-A1 | Castration-Resistant Prostate Cancer | NUTECH VENTURES | 2016-10-27 | — | — | US | disclosed |
| US-9353094-B2 | Substituted quinoxalines as kinase inhibitors | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150274709-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM | 2015-10-01 | — | — | US | disclosed |
| US-8993758-B2 | Substituted quinoxalines and uses thereof | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140050728-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CYCLOPHILIN D FOR THE TREATMENT AND PREVENTION OF OBESITY AND KIDNEY INDICATIONS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2014-02-20 | — | — | US | disclosed |
| US-20130289041-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2013-10-31 | — | — | US | disclosed |
| WO-2012103520-A1 | METHODS AND COMPOSITIONS FOR MODULATING CYCLOPHILIN D | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012071414-A2 | QUINOXALINE COMPOUNDS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160310528-A1 | Castration-Resistant Prostate Cancer | UGDH, G6PD, DPYD | PTPN7 3135/4885CACNA1B 4539/4885APBA1 4546/4885 |
| US-20150274709-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, MTOR | PTPN7 1891/4885CACNA1B 3637/4885APBA1 1981/4885 |
| US-20140050728-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CYCLOPHILIN D FOR THE TREATMENT AND PREVENTION OF OBESITY AND KIDNEY INDICATIONS | PPIG, FKBP1B, PPIH | PTPN7 1555/4885CACNA1B 4391/4885APBA1 2800/4885 |
| US-20130289041-A1 | QUINOXALINE COMPOUNDS AND USES THEREOF | NFKBIA, RELA, MTOR | PTPN7 1891/4885CACNA1B 3637/4885APBA1 1981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.