Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 6/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.44 |
| ▸ | HPN | P05981 | 1/20 | 0.44 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613683 | 0.79 | KDM1A (0.44) | KDM1AITGB3ITGA2BF10PRSS1 | |
| SCHEMBL9613680 | 0.79 | KMT2A (0.55) | F10PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL641306 | 0.76 | CCNC (0.57) | EPHX1KDM4EALDH1A1 | |
| SCHEMBL7288482 | 0.76 | EPHX1 (0.69) | EPHX1ALDH1A1 | |
| SCHEMBL7071501 | 0.75 | CA12 (0.67) | LMNAITGB3ITGA2BF10PRSS1 | |
| SCHEMBL7297189 | 0.75 | EPHX1 (0.57) | EPHX1KDM4EMGLL | |
| SCHEMBL9613681 | 0.74 | KDM1A (0.68) | KDM1AKDM4ELMNAITGB3ITGA2B | |
| SCHEMBL25909077 | 0.74 | EPHX2 (0.53) | MGLL | |
| SCHEMBL9613675 | 0.74 | F10 (0.63) | KDM4ELMNAF10ALDH1A1 | |
| Bromide SCHEMBL11386071 | 0.71 | BLM (0.60) | KDM4ELMNAALDH1A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012071469-A2 | HISTONE DEMETHYLASE INHIBITORS AND USES THEREOF FOR TREATMENT O F CANCER | NEVADA CANCER INSTITUTE (US) | 2012-05-31 | — | — | WO | disclosed |