Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10484232 | 0.89 | MTNR1A (0.42) | MTNR1AMCL1TDP1SIGMAR1GRM2 | |
| SCHEMBL10484346 | 0.79 | MCL1 (0.48) | MTNR1AMCL1TDP1GRM2GRM3 | |
| SCHEMBL10484234 | 0.79 | MCL1 (0.46) | MTNR1AMCL1TDP1GRM2GRM3 | |
| SCHEMBL10484191 | 0.76 | ACP3 (0.43) | MTNR1ATDP1GRM2GRM3ATM | |
| SCHEMBL10484243 | 0.73 | GRM2 (0.43) | MTNR1AMCL1TDP1GRM2GRM3 | |
| SCHEMBL10484195 | 0.72 | L3MBTL1 (0.32) | MTNR1ATDP1ATMKMT2AKDM4E | |
| SCHEMBL10529330 | 0.71 | MCL1 (0.43) | MTNR1AMCL1GRM2GRM3KMT2A | |
| SCHEMBL10484341 | 0.71 | SLC2A1 (0.38) | MTNR1AMCL1SIGMAR1NQO2KMT2A | |
| SCHEMBL10531949 | 0.70 | MCL1 (0.42) | MTNR1AMCL1TDP1SIGMAR1GRM2 | |
| SCHEMBL28309323 | 0.68 | ALDH1A1 (0.57) | MTNR1ATDP1ATMNQO2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4876282-A | ANTIDEPRESSANT, DIETETICS, ANTIALCOHOLISM AGENT | ELI LILLY AND COMPANY (US) | 1989-10-24 | — | — | US | claimed |
| US-4876282-A | ANTIDEPRESSANT, DIETETICS, ANTIALCOHOLISM AGENT | ELI LILLY AND COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| EP-0318234-A2 | Improvements in or relating to selective serotonin uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |