Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | PARP1 | P09874 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GPR3 | P46089 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29519421 | 0.86 | POLB (0.64) | POLBTDP1PARP1ALDH1A1KDM4E | |
| SCHEMBL3420569 | 0.86 | POLB (0.64) | POLBTDP1PARP1ALDH1A1KDM4E | |
| SCHEMBL1613016 | 0.82 | PARP1 (0.57) | POLBTDP1PARP1ALDH1A1KDM4E | |
| SCHEMBL3224273 | 0.75 | PARP1 (0.75) | POLBTDP1PARP1ALDH1A1KDM4E | |
| SCHEMBL11981333 | 0.75 | POLB (1.00) | POLBTDP1PARP1ALDH1A1KDM4E | |
| SCHEMBL8926269 | 0.75 | PARP1 (0.60) | TDP1PARP1ALDH1A1KDM4ELMNA | |
| SCHEMBL7252401 | 0.74 | ROCK2 (0.52) | POLBTDP1PARP1ALDH1A1KDM4E | |
| SCHEMBL30678031 | 0.74 | IMPDH2 (0.59) | POLBTDP1PARP1ALDH1A1KDM4E | |
| SCHEMBL3433644 | 0.74 | IMPDH2 (0.59) | POLBTDP1PARP1ALDH1A1KDM4E | |
| SCHEMBL14034689 | 0.72 | MEN1 (0.60) | POLBTDP1PARP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5080905-A | THERAPY OF 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AND DERIVATIVES AS DRUGS FOR USE IN THE TREATMENT OF URINARY INCONTINENCE | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.T.L. (IT) | 1992-01-14 | — | — | US | claimed |
| EP-0408525-A2 | Use in therapy of 10-amino-5,6-dihydro-11H-dibenzo(b,e)azepine-6,11-dione and derivatives as drugs for use in the treatment of urinary incontinence | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1991-01-16 | — | — | EP | claimed |
| EP-0089322-B1 | TRICYCLIC DERIVATIVES OF 5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPIN-6-ONE HAVING PHARMACOLOGICAL AVTIVITY, AND METHOD FOR THEIR PREPARATION | A. Menarini S.a.S. (IT) | 1987-06-16 | — | — | EP | claimed |
| EP-0089322-A1 | Tricyclic derivatives of 5,6-dihydro-11H-dibenzo(B,E)azepin-6-one having pharmacological avtivity, and method for their preparation | A. Menarini S.a.S. (IT) | 1983-09-21 | — | — | EP | claimed |
| JP-3052813-A | — | — | None | — | — | JP | disclosed |
| JP-3052813-A | — | — | None | — | — | JP | disclosed |
| EP-0408525-A3 | USE IN THERAPY OF 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AND DERIVATIVES AS DRUGS FOR USE IN THE TREATMENT OF URINARY INCONTINENCE | — | 1992-03-04 | — | — | EP | disclosed |
| US-5080905-A | THERAPY OF 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AND DERIVATIVES AS DRUGS FOR USE IN THE TREATMENT OF URINARY INCONTINENCE | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.T.L. (IT) | 1992-01-14 | — | — | US | disclosed |
| US-5080905-A | THERAPY OF 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AND DERIVATIVES AS DRUGS FOR USE IN THE TREATMENT OF URINARY INCONTINENCE | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.T.L. (IT) | 1992-01-14 | — | — | US | disclosed |
| US-5080905-A | THERAPY OF 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AND DERIVATIVES AS DRUGS FOR USE IN THE TREATMENT OF URINARY INCONTINENCE | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.T.L. (IT) | 1992-01-14 | — | — | US | disclosed |
| JP-H0352813-A | PHARMACEUTICAL COMPOSITION CONTAINING 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AS ACTIVE INGREDIENT AND USED IN TREATMENT OF URINARY INCONTINENCE | A MENARINI IND FARM RIUNITE SRL | 1991-03-07 | — | — | JP | disclosed |
| JP-H0352813-A | PHARMACEUTICAL COMPOSITION CONTAINING 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AS ACTIVE INGREDIENT AND USED IN TREATMENT OF URINARY INCONTINENCE | A MENARINI IND FARM RIUNITE SRL | 1991-03-07 | — | — | JP | disclosed |
| EP-0408525-A2 | Use in therapy of 10-amino-5,6-dihydro-11H-dibenzo(b,e)azepine-6,11-dione and derivatives as drugs for use in the treatment of urinary incontinence | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1991-01-16 | — | — | EP | disclosed |
| EP-0408525-A2 | Use in therapy of 10-amino-5,6-dihydro-11H-dibenzo(b,e)azepine-6,11-dione and derivatives as drugs for use in the treatment of urinary incontinence | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1991-01-16 | — | — | EP | disclosed |
| EP-0408525-A2 | Use in therapy of 10-amino-5,6-dihydro-11H-dibenzo(b,e)azepine-6,11-dione and derivatives as drugs for use in the treatment of urinary incontinence | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1991-01-16 | — | — | EP | disclosed |
| EP-0089322-B1 | TRICYCLIC DERIVATIVES OF 5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPIN-6-ONE HAVING PHARMACOLOGICAL AVTIVITY, AND METHOD FOR THEIR PREPARATION | A. Menarini S.a.S. (IT) | 1987-06-16 | — | — | EP | disclosed |