Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 5/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9616784 | 0.77 | HTR6 (0.54) | HSP90AA1HSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL9616674 | 0.77 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1MEN1KMT2AMCL1 | |
| SCHEMBL9616556 | 0.77 | MEN1 (0.56) | SLC40A1MEN1KMT2AMCL1ALDH1A1 | |
| SCHEMBL9616814 | 0.75 | BRD4 (0.42) | RECQLSLC40A1MEN1KMT2AALDH1A1 | |
| SCHEMBL9616695 | 0.74 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL8416358 | 0.73 | CYP2A6 (0.50) | HSP90AA1HSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL30737433 | 0.72 | PTGES2 (0.56) | SLC40A1MEN1KMT2AMCL1NFKBIA | |
| SCHEMBL9616615 | 0.72 | MEN1 (0.61) | HSP90AA1HSP90AB1MEN1KMT2AMAPT | |
| SCHEMBL4191121 | 0.72 | PTGES2 (0.69) | MEN1KMT2AALDH1A1MAPTPTGES2 | |
| SCHEMBL499404 | 0.71 | CYP2A6 (0.52) | MEN1KMT2AALDH1A1MAPTKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | claimed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | claimed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | claimed |