Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9616615 | 0.85 | MEN1 (0.61) | MEN1KMT2AHSP90AA1HSP90AB1LMNA | |
| SCHEMBL28530757 | 0.83 | HTR6 (0.61) | HTR6MEN1KMT2APOLBCDC25A | |
| SCHEMBL9616610 | 0.83 | WDR5 (0.53) | MEN1KMT2AHSP90AA1HSP90AB1WDR5 | |
| SCHEMBL9616559 | 0.81 | MEN1 (0.48) | HTR6MEN1KMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL9616544 | 0.81 | WDR5 (0.67) | MEN1KMT2APOLBWDR5 | |
| SCHEMBL9616673 | 0.80 | WDR5 (0.53) | MEN1KMT2APOLBWDR5LMNA | |
| SCHEMBL9616674 | 0.79 | HSP90AA1 (0.49) | MEN1KMT2AHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL9616631 | 0.78 | WDR5 (0.67) | HTR6MEN1KMT2APOLBWDR5 | |
| SCHEMBL9616695 | 0.77 | HSP90AA1 (0.47) | MEN1KMT2AHSP90AA1HSP90AB1POLB | |
| SCHEMBL9616628 | 0.77 | RECQL (0.44) | HTR6MEN1KMT2AHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | claimed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | claimed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | claimed |