Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 11/20 | 0.56 |
| ▸ | CA1 | P00915 | 10/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9616784 | 0.85 | HTR6 (0.54) | MEN1KMT2ACA2CA1HSP90AA1 | |
| SCHEMBL9616610 | 0.81 | WDR5 (0.53) | MEN1KMT2ACA2CA1HSP90AA1 | |
| SCHEMBL9616708 | 0.80 | MEN1 (0.64) | MEN1KMT2ACA2CA1CA9 | |
| SCHEMBL9616544 | 0.79 | WDR5 (0.67) | MEN1KMT2AMAPT | |
| SCHEMBL9616559 | 0.79 | MEN1 (0.48) | MEN1KMT2AHSP90AA1HSP90AB1MAPT | |
| SCHEMBL9616673 | 0.78 | WDR5 (0.53) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL9616674 | 0.77 | HSP90AA1 (0.49) | MEN1KMT2AHSP90AA1HSP90AB1MAPT | |
| SCHEMBL9616695 | 0.75 | HSP90AA1 (0.47) | MEN1KMT2AHSP90AA1HSP90AB1MAPT | |
| SCHEMBL2308296 | 0.75 | CA2 (0.79) | MEN1KMT2ACA2CA1CA9 | |
| SCHEMBL8416358 | 0.74 | CYP2A6 (0.50) | MEN1KMT2ACA2CA1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | claimed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | claimed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | claimed |
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | disclosed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | disclosed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | disclosed |