SCHEMBL9617031

SCHEMBL9617031

FC1(F)C(F)(F)C(F)(F)C(c2ccc(Br)cc2)(c2ccc(Br)cc2)C1(F)F

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.42
ALDH1A1 P00352 4/20 0.33
ALOX15 P16050 2/20 0.33
MAPK1 P28482 2/20 0.33
TDP1 Q9NUW8 1/20 0.30
CNR1 P21554 1/20 0.30
GSK3B P49841 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9848301 0.75 CYP2A6 (0.38) CYP2A6ALDH1A1ALOX15MAPK1GSK3B
SCHEMBL10554150 0.74 ALOX15 (0.42) ALDH1A1ALOX15
SCHEMBL3685814 0.74 ALOX15 (0.42) ALDH1A1ALOX15
SCHEMBL3684089 0.74 ALOX15 (0.42) ALDH1A1ALOX15
SCHEMBL9848309 0.74 MAOB (0.46) ALDH1A1TDP1
SCHEMBL9848304 0.72 MAOB (0.42)
SCHEMBL9848315 0.69 TP53 (0.39) CYP2A6ALDH1A1MAPK1TDP1
SCHEMBL24077324 0.68 CYP2A6 (0.42) CYP2A6ALDH1A1ALOX15MAPK1TDP1
SCHEMBL9848308 0.67 CA12 (0.42) ALDH1A1ALOX15TDP1
SCHEMBL9848307 0.66 ALDH1A1 (0.39) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4210930-A None JP disclosed
JP-H04210930-A 1,1-BICYCLO-SUBSTITUTED FLUORINE-CONTAINING CYCLOPENTANE AND ITS PREPARATION BAYER AG 1992-08-03 JP disclosed
EP-0438715-A2 1,1-Bicyclo-substituted fluorinated cyclopentanes and method for their production BAYER AG (DE) 1991-07-31 EP disclosed