SCHEMBL9848301

SCHEMBL9848301

OC1(c2ccc(Br)cc2)C(F)(F)C(F)(F)C(F)(F)C1(F)F

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.38
ALOX15 P16050 2/20 0.36
GSK3B P49841 1/20 0.32
CA1 P00915 2/20 0.32
CA2 P00918 2/20 0.32
TSHR P16473 1/20 0.32
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
OPRM1 P35372 1/20 0.32
OPRD1 P41143 1/20 0.32
OPRK1 P41145 1/20 0.32
OPRL1 P41146 1/20 0.32
TAAR1 Q96RJ0 1/20 0.32
ALDH1A1 P00352 2/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9848306 0.75 MAOB (0.39) TSHROPRM1OPRK1OPRL1
SCHEMBL9617031 0.75 CYP2A6 (0.42) CYP2A6ALOX15GSK3BALDH1A1MAPK1
SCHEMBL22448146 0.67 OPRM1 (0.46) CA1CA2OPRM1OPRD1OPRK1
SCHEMBL24077324 0.65 CYP2A6 (0.42) CYP2A6ALOX15GSK3BOPRM1OPRD1
SCHEMBL15573716 0.65 OPRM1 (0.53) CYP2A6ALOX15CA1CA2OPRM1
SCHEMBL12526871 0.65 OPRM1 (0.53) CYP2A6ALOX15CA1CA2OPRM1
SCHEMBL28277379 0.63 CYP2A6 (0.40) CYP2A6ALOX15ALDH1A1MAPK1
SCHEMBL1740643 0.62 OPRM1 (0.50) CYP2A6CA1CA2OPRM1OPRD1
SCHEMBL10072781 0.62 ALDH1A1 (0.39) CYP2A6ALOX15OPRM1OPRD1OPRK1
SCHEMBL748761 0.62 OPRM1 (0.50) CYP2A6CA1CA2OPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0438715-A2 1,1-Bicyclo-substituted fluorinated cyclopentanes and method for their production BAYER AG (DE) 1991-07-31 EP disclosed