Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Tetrylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrylammonium SCHEMBL2353698 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Tetrylammonium SCHEMBL2349571 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Tetrylammonium SCHEMBL2351492 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Tetrylammonium SCHEMBL2348763 | 1.00 | TSHR (0.53) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Tetrylammonium SCHEMBL2351938 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Tetrylammonium SCHEMBL2346203 | 0.97 | TSHR (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Tetrylammonium SCHEMBL2349569 | 0.88 | TSHR (0.41) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Tetrylammonium SCHEMBL2452720 | 0.88 | TSHR (0.41) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Tetrylammonium SCHEMBL2351488 | 0.88 | TSHR (0.41) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Tetrylammonium SCHEMBL6552606 | 0.87 | TSHR (0.40) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4017316-A | — | — | None | — | — | JP | disclosed |
| JP-1037822-A | — | — | None | — | — | JP | disclosed |
| CN-1720597-A | Flame-retardant electrolyte electrolytic capacitor | BRIDGESTONE CORP (JP) | 2006-01-11 | — | — | CN | disclosed |
| CN-1063871-C | An ionic conductive polymer electrolyte | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 2001-03-28 | — | — | CN | disclosed |
| CN-1083259-A | A kind of ion conducting polymer electrolyte | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 1994-03-02 | — | — | CN | disclosed |
| JP-H0417316-A | ELECTROLYTE FOR DRIVING ELECTROLYTIC CAPACITOR AND ELECTROLYTIC CAPACITOR IMPREGNATED THEREWITH | MARCON ELECTRON CO LTD | 1992-01-22 | — | — | JP | disclosed |
| JP-S6437822-A | ELECTROLYTIC CAPACITOR | ASAHI GLASS CO LTD | 1989-02-08 | — | — | JP | disclosed |