Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 4/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108033 | 0.89 | RAB9A (0.55) | RAB9AMEN1KMT2ALMNAMAPT | |
| SCHEMBL12544643 | 0.85 | RAB9A (0.56) | RAB9AMEN1KMT2ALMNAMAPT | |
| SCHEMBL15423843 | 0.85 | RAB9A (0.60) | SLC22A2SLC22A1SLC22A3SLC6A4RAB9A | |
| SCHEMBL12239728 | 0.85 | RAB9A (0.50) | RAB9AMEN1KMT2ALMNAMAPT | |
| SCHEMBL12948078 | 0.84 | ALDH1A1 (0.52) | RAB9AMEN1KMT2ALMNAMAPT | |
| SCHEMBL13355627 | 0.83 | MEN1 (0.68) | RAB9AMEN1KMT2ALMNAMAPT | |
| SCHEMBL12240446 | 0.80 | SRD5A2 (0.56) | RAB9AMEN1KMT2ALMNAMAPT | |
| SCHEMBL16000663 | 0.78 | QDPR (0.50) | SLC22A2SLC22A1SLC22A3SLC6A4RAB9A | |
| SCHEMBL5159624 | 0.78 | SLC22A2 (0.70) | SLC22A2SLC22A1SLC22A3SLC6A4APOBEC3A | |
| SCHEMBL5164430 | 0.78 | ALDH1A1 (0.64) | SLC22A2SLC22A1SLC22A3SLC6A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4283565-A | — | — | None | — | — | JP | disclosed |
| JP-H04283565-A | VIOLOGEN DERIVATIVE HAVING BENZOPHENONE STRUCTURE AND ITS PRODUCTION | ASAHI DENKA KOGYO KK | 1992-10-08 | — | — | JP | disclosed |