Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | NOS2 | P35228 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10870900 | 1.00 | NOS3 (0.42) | NOS3NOS1NOS2PKMALPI | |
| SCHEMBL27849759 | 0.85 | ALPI (0.35) | NOS3NOS1NOS2PKMALPI | |
| SCHEMBL10870881 | 0.85 | ALPI (0.35) | NOS3NOS1NOS2PKMALPI | |
| SCHEMBL27293020 | 0.81 | NOS3 (0.50) | NOS3NOS1NOS2PKMALPI | |
| SCHEMBL27293026 | 0.81 | NOS3 (0.50) | NOS3NOS1NOS2PKMALPI | |
| SCHEMBL27308574 | 0.79 | OPRK1 (0.40) | KMT2ATSHRALDH1A1CYP2C9HSD17B10 | |
| SCHEMBL27328776 | 0.79 | OPRK1 (0.40) | KMT2ATSHRALDH1A1CYP2C9HSD17B10 | |
| SCHEMBL10359245 | 0.77 | TPH1 (0.48) | PKMALPIPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL28207394 | 0.76 | SLC7A5 (0.61) | NOS3NOS1NOS2PKMALPI | |
| Phenylalanine SCHEMBL27624223 | 0.76 | SLC7A5 (0.61) | NOS3NOS1NOS2PKMALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186378-B1 | PROCESS FOR THE PREPARATION OF N-FORMYL-ALPHA-ASPARTYL PHENYLALANINE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1992-01-15 | — | — | EP | claimed |
| US-4745210-A | AMIDATION OF PHENYLALANINE WITH ANHYDRIDE | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1988-05-17 | — | — | US | claimed |
| EP-0186378-A2 | Process for the preparation of N-formyl-alpha-aspartyl phenylalanine | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1986-07-02 | — | — | EP | claimed |
| EP-0186378-B1 | PROCESS FOR THE PREPARATION OF N-FORMYL-ALPHA-ASPARTYL PHENYLALANINE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-4778916-A | CONDENSATION OF N-FORMYL-L-ASPARTIC ACID ANHYDRIDE WITH PHENYLALANINE IN BASIC AQUEOUS SOLUTION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1988-10-18 | — | — | US | disclosed |
| US-4745210-A | AMIDATION OF PHENYLALANINE WITH ANHYDRIDE | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1988-05-17 | — | — | US | disclosed |
| EP-0200311-A2 | Preparation process of alpha-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1986-11-05 | — | — | EP | disclosed |
| EP-0186378-A2 | Process for the preparation of N-formyl-alpha-aspartyl phenylalanine | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1986-07-02 | — | — | EP | disclosed |