Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.69 |
| ▸ | DRD2 | P14416 | 3/20 | 0.69 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.69 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620730 | 0.94 | HTR1A (0.61) | HTR1ACHRM1DRD2ADRA1DADRA1A | |
| SCHEMBL9620681 | 0.91 | HTR1A (0.67) | HTR1ACHRM1DRD2ADRA1DADRA1A | |
| SCHEMBL9620744 | 0.85 | HTR1A (0.59) | HTR1ACHRM1DRD2ADRA1DADRA1A | |
| SCHEMBL10744377 | 0.82 | ADRA1A (1.00) | HTR1ACHRM1DRD2ADRA1DADRA1A | |
| SCHEMBL10778045 | 0.80 | RXFP1 (0.64) | HTR1ACHRM1DRD2ADRA1DADRA1A | |
| Fluprofylline SCHEMBL683614 | 0.80 | HTR1A (0.64) | HTR1ACHRM1DRD2ADRA1DADRA1A | |
| SCHEMBL11155310 | 0.79 | HTR7 (0.74) | HTR1ACHRM1DRD2ADRA1DADRA1A | |
| SCHEMBL10778041 | 0.79 | RXFP1 (0.56) | HTR1ACHRM1DRD2ADRA1DADRA1A | |
| Perbufylline SCHEMBL682795 | 0.78 | HTR1A (0.61) | HTR1ACHRM1DRD2ADRA1DADRA1A | |
| SCHEMBL11149716 | 0.78 | HTR1A (0.61) | HTR1ACHRM1DRD2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0271192-B1 | PURINE HISTAMINE H1 ANTAGONISTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-08 | — | — | EP | claimed |
| US-4716166-A | PURINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-12-29 | — | — | US | claimed |
| US-4716166-A | PURINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-12-29 | — | — | US | disclosed |