Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.59 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620681 | 0.94 | HTR1A (0.67) | HTR1ACHRM1ADRA1ADRD2ADRA1D | |
| SCHEMBL9620730 | 0.90 | HTR1A (0.61) | HTR1ACHRM1ADRA1ADRD2ADRA1D | |
| SCHEMBL9620955 | 0.85 | HTR1A (0.69) | HTR1ACHRM1ADRA1ADRD2ADRA1D | |
| SCHEMBL7316541 | 0.81 | ALDH1A1 (0.59) | HTR1ACHRM1ADRA1ADRD2ADRA1D | |
| SCHEMBL683621 | 0.78 | RXFP1 (0.52) | HTR1ACHRM1ADRA1ADRD2ADRA1D | |
| SCHEMBL10778045 | 0.77 | RXFP1 (0.64) | HTR1ACHRM1ADRA1ADRD2ADRA1D | |
| SCHEMBL4461767 | 0.77 | ADORA2B (0.73) | HTR7HTR6ALDH1A1ADORA2BRXFP1 | |
| SCHEMBL1810048 | 0.77 | HTR7 (0.84) | HTR1AHTR7HTR6ALDH1A1ADORA2B | |
| SCHEMBL684006 | 0.77 | CHRM2 (0.72) | HTR1ACHRM1ADRA1ADRD2ADRA1D | |
| SCHEMBL10778041 | 0.76 | RXFP1 (0.56) | HTR1ACHRM1ADRA1ADRD2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0271192-B1 | PURINE HISTAMINE H1 ANTAGONISTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-08 | — | — | EP | claimed |
| US-4716166-A | PURINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-12-29 | — | — | US | claimed |
| EP-0271192-B1 | PURINE HISTAMINE H1 ANTAGONISTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-08 | — | — | EP | disclosed |
| EP-0271192-A2 | Purine histamine H1 antagonists, their preparation and pharmaceutical compositions containing them | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4716166-A | PURINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-12-29 | — | — | US | disclosed |