Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPN | P05981 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 6/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GSR | P00390 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701573 | 0.85 | HPN (0.44) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9701568 | 0.84 | MAPT (0.45) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9168126 | 0.83 | ALOX15 (0.50) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL8834137 | 0.82 | MAPT (0.57) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9492905 | 0.80 | ALOX15 (0.47) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL646924 | 0.80 | ALOX15 (0.63) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9701236 | 0.79 | ALOX15 (0.44) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL8834596 | 0.79 | MAPT (0.53) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9621401 | 0.78 | VCAM1 (0.52) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL8834331 | 0.78 | ALOX15 (0.52) | ALOX15MAPTHPNSIRT5VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036105-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1991-07-30 | — | — | US | claimed |
| US-5162365-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1992-11-10 | — | — | US | disclosed |
| US-5036105-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1991-07-30 | — | — | US | disclosed |
| US-4801611-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1989-01-31 | — | — | US | disclosed |