Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPN | P05981 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9168126 | 0.87 | ALOX15 (0.50) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9701236 | 0.87 | ALOX15 (0.44) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9621875 | 0.84 | VCAM1 (0.43) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9701565 | 0.84 | HPN (0.44) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL646924 | 0.81 | ALOX15 (0.63) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9621562 | 0.80 | ALOX15 (0.46) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9494838 | 0.78 | MAPT (0.47) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL8702044 | 0.78 | ALOX15 (0.59) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9701573 | 0.78 | HPN (0.44) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9550781 | 0.78 | THRB (0.35) | ALOX15ALDH1A1TSHRCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5189038-A | Administering phenolic thioethers | G. D. SEARLE AND CO. (US) | 1993-02-23 | — | — | US | claimed |
| US-5229421-A | Antiallergens, antiinflammatory agents | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5208262-A | Administering 4-hydroxythiophenol derivatives | G. D. SEARLE & CO. (US) | 1993-05-04 | — | — | US | disclosed |
| US-5189038-A | Administering phenolic thioethers | G. D. SEARLE AND CO. (US) | 1993-02-23 | — | — | US | disclosed |
| US-5082854-A | Enzyme inhibitors | G. D. SEARLE & CO. (US) | 1992-01-21 | — | — | US | disclosed |
| EP-0218782-B1 | LIPOXYGENASE-INHIBITING COMPOSITION AND HYDROXYPHENYLTHIOALKYLCARBONYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4857558-A | ANTIINFLAMMATORY AGENTS AND-OR ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1989-08-15 | — | — | US | disclosed |