Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.30 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TYR | P14679 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9847668 | 0.88 | HPN (0.39) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL646924 | 0.71 | ALOX15 (0.63) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL8834366 | 0.70 | HPN (0.44) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL8390048 | 0.70 | ALOX15 (0.53) | HPNMAPTALOX15SIRT5TDP1 | |
| SCHEMBL5574415 | 0.70 | ALOX15 (0.45) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL6274710 | 0.70 | ALOX15 (0.45) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9621523 | 0.69 | HPN (0.37) | HPNMAPTALOX15SIRT5 | |
| SCHEMBL9621054 | 0.69 | HPN (0.37) | HPNMAPTALOX15SIRT5 | |
| SCHEMBL14417966 | 0.69 | ALOX15 (0.44) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL5574287 | 0.69 | ALOX15 (0.44) | HPNMAPTALOX15SIRT5VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162365-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1992-11-10 | — | — | US | claimed |
| US-5162365-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1992-11-10 | — | — | US | disclosed |
| US-5036105-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1991-07-30 | — | — | US | disclosed |
| US-4801611-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1989-01-31 | — | — | US | disclosed |