Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | MAOB | P27338 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10465161 | 0.88 | ALDH1A1 (0.58) | ALDH1A1LMNASMN1; SMN2MAPTGAA | |
| SCHEMBL30797089 | 0.81 | RAB9A (0.64) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL13753681 | 0.80 | ALDH1A1 (0.71) | ALDH1A1LMNASMN1; SMN2MAOBHPGD | |
| SCHEMBL8167087 | 0.79 | CYP1A2 (0.85) | ALDH1A1LMNASMN1; SMN2MAOBHPGD | |
| SCHEMBL11771677 | 0.78 | ALDH1A1 (0.72) | ALDH1A1LMNASMN1; SMN2MAOBHPGD | |
| SCHEMBL3063622 | 0.76 | ALDH1A1 (0.65) | ALDH1A1LMNASMN1; SMN2MAOBHPGD | |
| SCHEMBL3398772 | 0.75 | ALDH1A1 (0.63) | ALDH1A1LMNASMN1; SMN2MAOBHPGD | |
| SCHEMBL9425121 | 0.75 | LMNA (0.53) | ALDH1A1LMNASMN1; SMN2MAOBHPGD | |
| SCHEMBL14434551 | 0.75 | ALDH1A1 (0.53) | ALDH1A1LMNASMN1; SMN2HPGDMAPT | |
| SCHEMBL12177297 | 0.74 | HPGD (1.00) | ALDH1A1LMNASMN1; SMN2MAOBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260814-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-05 | — | — | EP | disclosed |
| US-4992459-A | Hypotensive agents, antiulcer agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0212066-B1 | INTERMEDIATES USEFUL IN THE PREPARATION OF DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-11-22 | — | — | EP | disclosed |
| EP-0288488-A4 | DOPAMINE- -HYDROXYLASE INHIBITORS | — | 1990-09-12 | — | — | EP | disclosed |
| US-4935438-A | Dopamine-β-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |
| US-4912226-A | A 1-(benyzlsubstituted-),2-((1,3-dioneisoindolin-2-yl)alkyl thio-)imidazole | SMITHKLINE BECKMAN CORPORATION (US) | 1990-03-27 | — | — | US | disclosed |
| US-4882348-A | HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-11-21 | — | — | US | disclosed |
| WO-1989006128-A1 | 2-CARBOXYALKYLTHIOIMIDAZOLES AND ESTERS THEREOF AS DOPAMINE-beta-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-07-13 | — | — | WO | disclosed |
| EP-0323146-A2 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-07-05 | — | — | EP | disclosed |
| EP-0125033-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-26 | — | — | EP | disclosed |
| EP-0308573-A2 | Intermediates useful in the preparation of dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-03-29 | — | — | EP | disclosed |
| EP-0288488-A1 | DOPAMINE- -HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |
| US-4772723-A | Dopamine β-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1988-09-20 | — | — | US | disclosed |
| WO-1988001267-A1 | DOPAMINE-ss-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | disclosed |
| EP-0212066-A1 | Intermediates useful in the preparation of dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1987-03-04 | — | — | EP | disclosed |
| US-4532331-A | 1-Benzyl-2-aminomethyl imidazole derivatives | SMITHKLINE BECKMAN CORPORATION (US) | 1985-07-30 | — | — | US | disclosed |
| EP-0125783-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1984-11-21 | — | — | EP | disclosed |
| EP-0125033-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1984-11-14 | — | — | EP | disclosed |