Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL872897 | 0.89 | LMNA (0.52) | LMNATDP1AKR1B1TSHR | |
| Propylene Glycol SCHEMBL118981 | 0.87 | LMNA (0.67) | LMNATDP1ALDH1A1TSHR | |
| Propionaldehyde SCHEMBL1523503 | 0.87 | LMNA (0.67) | LMNATDP1ALDH1A1MAPK1 | |
| Propylene Glycol SCHEMBL17219435 | 0.86 | LMNA (0.44) | LMNATDP1 | |
| Propylene Glycol SCHEMBL16536046 | 0.84 | — | — | |
| Propylene Glycol SCHEMBL9721324 | 0.84 | LMNA (0.46) | LMNATDP1ALDH1A1TSHR | |
| Propylene Glycol SCHEMBL1532415 | 0.83 | LMNA (0.55) | LMNATDP1ALDH1A1TSHR | |
| 2-Methylbutanal SCHEMBL21434919 | 0.82 | LMNA (0.44) | LMNATDP1AKR1B1TSHR | |
| SCHEMBL629168 | 0.82 | LMNA (0.60) | LMNATDP1ALDH1A1MAPK1 | |
| Propionaldehyde SCHEMBL8906570 | 0.82 | LMNA (0.60) | LMNATDP1ALDH1A1MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106866366-B | Method for removing dihydric alcohol or polyhydric alcohol impurities in ethylene glycol and increasing yield of ethylene glycol | 中国科学院大连化学物理研究所 | 2020-05-05 | — | — | CN | claimed |
| CN-106866366-B | Method for removing dihydric alcohol or polyhydric alcohol impurities in ethylene glycol and increasing yield of ethylene glycol | 中国科学院大连化学物理研究所 | 2020-05-05 | — | — | CN | disclosed |
| EP-2939537-B1 | FLYING INSECT CATCHER | DAINIPPON JOCHUGIKU KK (JP) | 2020-04-01 | — | — | EP | disclosed |
| EP-2939537-A1 | FLYING INSECT CATCHER | DAINIHON JOCHUGIKU CO., LTD. (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-0170243-B1 | FERMENTATION PROCESS FOR PREPARATION OF ALKYL ESTERS OF CARBOXYLIC ACIDS | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1992-03-18 | — | — | EP | disclosed |
| US-4686307-A | Preparation of naturally-occurring C2 -C5 alkyl esters of C4 -C5 carboxylic acids by means of fermentation of C5 -C6 amino acids in the presence of C2 -C5 alcohols | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4657862-A | ORGANOLEPTIC UTILITIES | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0170243-A2 | Fermentation process for preparation of alkyl esters of carboxylic acids | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1986-02-05 | — | — | EP | disclosed |