Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL1245845 | 0.91 | LMNA (0.50) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Propylene Glycol SCHEMBL16666994 | 0.91 | LMNA (0.50) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Propylene Glycol SCHEMBL118981 | 0.91 | LMNA (0.67) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Acetone SCHEMBL590699 | 0.88 | LMNA (0.71) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Acetone SCHEMBL16666366 | 0.86 | LMNA (0.60) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Propylene Glycol SCHEMBL872897 | 0.84 | LMNA (0.52) | LMNATDP1TSHRTHRB | |
| Propylene Glycol SCHEMBL10380801 | 0.84 | LMNA (0.57) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Acetone SCHEMBL1036956 | 0.83 | LMNA (0.63) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Acetone SCHEMBL3833129 | 0.83 | LMNA (0.63) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Propylene Glycol SCHEMBL9621813 | 0.83 | LMNA (0.50) | LMNATDP1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017841-B | Organic solvent dispersion of titanium oxide solid solution particles, method of preparation and coating composition | 信越化学工业株式会社 | 2020-01-17 | — | — | CN | disclosed |
| US-10309212-B2 | Energetic cocrystals for treatment of a subterranean formation | HALLIBURTON ENERGY SERVICES, INC. (US) | 2019-06-04 | — | — | US | disclosed |
| CN-104610877-B | The product of coating composition and coating containing titanium oxide | 信越化学工业株式会社 | 2019-04-23 | — | — | CN | disclosed |
| US-10253244-B2 | Scale-inhibiting cocrystals for treatment of a subterranean formation | HALLIBURTON ENERGY SERVICES, INC. (US) | 2019-04-09 | — | — | US | disclosed |
| EP-2933230-B1 | ORGANIC SOLVENT DISPERSION OF TITANIUM OXIDE SOLID-SOLUTION PARTICLES, MAKING METHOD AND COATING COMPOSITION | SHINETSU CHEMICAL CO (JP) | 2018-01-03 | — | — | EP | disclosed |
| EP-2865720-B1 | Photocurable coating composition, laminate, and automotive headlamp covering sheet | SHINETSU CHEMICAL CO (JP) | 2017-05-03 | — | — | EP | disclosed |
| EP-2868717-B1 | Titania-containing coating composition and coated article | SHINETSU CHEMICAL CO (JP) | 2017-04-19 | — | — | EP | disclosed |
| US-20160177698-A1 | ENERGETIC COCRYSTALS FOR TREATMENT OF A SUBTERRANEAN FORMATION | HALLIBURTON ENERGY SERVICES, INC. | 2016-06-23 | — | — | US | disclosed |
| US-20160130496-A1 | SCALE-INHIBITING COCRYSTALS FOR TREATMENT OF A SUBTERRANEAN FORMATION | HALLIBURTON ENERGY SERVICES, INC. | 2016-05-12 | — | — | US | disclosed |
| EP-2292585-B1 | Screening for solid forms by ultrasound crystallization and cocrystallization using ultrasound | APTUIT WEST LAFAYETTE LLC (US) | 2016-04-27 | — | — | EP | disclosed |
| EP-2868717-A1 | Titania-containing coating composition and coated article | Shin-Etsu Chemical Co., Ltd. (JP) | 2015-05-06 | — | — | EP | disclosed |
| US-20150118483-A1 | PHOTOCURABLE COATING COMPOSITION, LAMINATE, AND AUTOMOTIVE HEADLAMP COVERING SHEET | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2015-04-30 | — | — | US | disclosed |
| EP-2865720-A1 | Photocurable coating composition, laminate, and automotive headlamp covering sheet | Shin-Etsu Chemical Co., Ltd. (JP) | 2015-04-29 | — | — | EP | disclosed |
| CN-104559364-A | PHOTOCURABLE COATING COMPOSITION, LAMINATE, AND AUTOMOTIVE HEADLAMP COVERING SHEET | SHINETSU CHEMICAL CO | 2015-04-29 | — | — | CN | disclosed |
| WO-2015034478-A1 | SCALE-INHIBITING COCRYSTALS FOR TREATMENT OF A SUBTERRANEAN FORMATION | HALLIBURTON ENERGY SERVICES, INC. (US) | 2015-03-12 | — | — | WO | disclosed |
| WO-2015030730-A1 | ENERGETIC COCRYSTALS FOR TREATMENT OF A SUBTERRANEAN FORMATION | HALLIBURTON ENERGY SERVICES, INC. (US) | 2015-03-05 | — | — | WO | disclosed |
| US-8920559-B2 | Screening for solid forms by ultrasound crystallization and cocrystallization using ultrasound | APTUIT (WEST LAFAYETTE), LLC (US) | 2014-12-30 | — | — | US | disclosed |
| US-20110251426-A1 | SCREENING FOR SOLID FORMS BY ULTRASOUND CRYSTALLIZATION AND COCRYSTALLIZATION USING ULTRASOUND | S.S.C.I., INC. (US) | 2011-10-13 | — | — | US | disclosed |
| EP-2292585-A1 | Screening for solid forms by ultrasound crystallization and cocrystallization using ultrasound | APTUIT (KANSAS CITY), LLC (US) | 2011-03-09 | — | — | EP | disclosed |
| US-20070088508-A1 | Cocrystallization methods | APTUIT (WEST LAFAYETTE), LLC | 2007-04-19 | — | — | US | disclosed |