SCHEMBL9623315

SCHEMBL9623315

CN(C)CCN1C(=O)c2cc(C3CC3)c3[nH]c4ccc(O)cc4c3c2C1=O

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MYLK Q15746 1/20 0.45
ROCK2 O75116 7/20 0.41
TERT O14746 1/20 0.39
CHEK1 O14757 8/20 0.39
WEE1 P30291 6/20 0.39
SRC P12931 1/20 0.38
GSK3A P49840 1/20 0.37
GSK3B P49841 1/20 0.37
CDK5 Q00535 1/20 0.37
CDK5R1 Q15078 1/20 0.37
PRKCA P17252 2/20 0.36
MAP3K5 Q99683 2/20 0.36
IKBKB O14920 1/20 0.36
PIM1 P11309 1/20 0.36
PRKCQ Q04759 1/20 0.36
PRKCD Q05655 1/20 0.36
ROCK1 Q13464 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9623232 0.99 MYLK (0.44) MYLKROCK2TERTCHEK1WEE1
SCHEMBL9623234 0.96 MYLK (0.44) MYLKROCK2TERTCHEK1WEE1
Hydrochloric Acid SCHEMBL9623216 0.95 MYLK (0.43) MYLKROCK2TERTCHEK1WEE1
SCHEMBL29351301 0.85 MYLK (0.46) MYLKROCK2TERTCHEK1WEE1
SCHEMBL9623107 0.85 MYLK (0.46) MYLKROCK2TERTCHEK1WEE1
Hydrochloric Acid SCHEMBL9623312 0.84 MYLK (0.45) MYLKROCK2TERTCHEK1WEE1
SCHEMBL9623136 0.84 MYLK (0.45) MYLKROCK2TERTCHEK1WEE1
SCHEMBL9622994 0.83 ROCK2 (0.45) MYLKROCK2TERTCHEK1WEE1
SCHEMBL9622720 0.82 WEE1 (0.58) MYLKROCK2CHEK1WEE1SRC
SCHEMBL9622489 0.82 MYLK (0.45) MYLKROCK2TERTCHEK1WEE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5166204-A ISOINDOLE DERIVATIVES AND SALTS THEREOF AND ANTITUMOR AGENT COMPRISING THE SAME TOYAMA CHEMICAL CO., LTD. (JP) 1992-11-24 US claimed