Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.68 |
| ▸ | PGR | P06401 | 4/20 | 0.68 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.68 |
| ▸ | AR | P10275 | 3/20 | 0.63 |
| ▸ | F2 | P00734 | 1/20 | 0.63 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | IL6 | P05231 | 1/20 | 0.46 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | GLUL | P15104 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11271565 | 0.83 | HIF1A (0.81) | CYP3A4HSD17B10HIF1APGRNR3C1 | |
| SCHEMBL3397741 | 0.83 | HIF1A (0.81) | CYP3A4HSD17B10HIF1APGRNR3C1 | |
| SCHEMBL3406702 | 0.83 | CYP3A4 (0.81) | CYP3A4HSD17B10HIF1APGRNR3C1 | |
| SCHEMBL3397738 | 0.83 | HIF1A (0.81) | CYP3A4HSD17B10HIF1APGRNR3C1 | |
| SCHEMBL3406698 | 0.83 | CYP3A4 (0.81) | CYP3A4HSD17B10HIF1APGRNR3C1 | |
| SCHEMBL13069748 | 0.83 | HIF1A (0.81) | CYP3A4HSD17B10HIF1APGRNR3C1 | |
| SCHEMBL9623866 | 0.82 | NR3C1 (0.67) | CYP3A4HSD17B10HIF1APGRNR3C1 | |
| Methylprednisolone SCHEMBL22163761 | 0.82 | HIF1A (0.98) | CYP3A4HSD17B10HIF1APGRNR3C1 | |
| SCHEMBL11691394 | 0.82 | CYP3A4 (0.78) | CYP3A4HSD17B10HIF1APGRNR3C1 | |
| SCHEMBL11691405 | 0.82 | CYP3A4 (0.78) | CYP3A4HSD17B10HIF1APGRNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268400-B1 | STEROIDAL 17ALPHA-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGESTERONES | THE UPJOHN COMPANY (US) | 1992-04-29 | — | — | EP | claimed |
| US-4548748-A | Cyanohydrin process | THE UPJOHN COMPANY (US) | 1985-10-22 | — | — | US | claimed |
| EP-0268400-B1 | STEROIDAL 17ALPHA-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGESTERONES | THE UPJOHN COMPANY (US) | 1992-04-29 | — | — | EP | disclosed |
| US-4831131-A | 11β,17α-Dihydroxy-17β-cyano-androstanes | THE UPJOHN COMPANY (US) | 1989-05-16 | — | — | US | disclosed |
| US-4585590-A | Cyanohydrin process | THE UPJOHN COMPANY (US) | 1986-04-29 | — | — | US | disclosed |
| US-4548748-A | Cyanohydrin process | THE UPJOHN COMPANY (US) | 1985-10-22 | — | — | US | disclosed |
| EP-0153001-A2 | Steroids having an enamide or enimide group and their preparation | THE UPJOHN COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |
| US-4500461-A | Cyanohydrin process | THE UPJOHN COMPANY (US) | 1985-02-19 | — | — | US | disclosed |