Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.37 |
| ▸ | PGR | P06401 | 4/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12265813 | 0.86 | NFKB1 (0.46) | NFKB1NFKB2RELAKCNH2CYP19A1 | |
| SCHEMBL9623669 | 0.82 | NFKB1 (0.56) | NFKB1NFKB2RELAKCNH2CYP19A1 | |
| SCHEMBL13069741 | 0.82 | HIF1A (0.52) | NFKB1NFKB2RELAKCNH2CYP19A1 | |
| SCHEMBL3394762 | 0.82 | HIF1A (0.52) | NFKB1NFKB2RELAKCNH2CYP19A1 | |
| SCHEMBL9073247 | 0.80 | HIF1A (0.55) | NFKB1NFKB2RELAKCNH2FNTA | |
| SCHEMBL12266195 | 0.80 | HIF1A (0.55) | NFKB1NFKB2RELAKCNH2FNTA | |
| SCHEMBL8859711 | 0.80 | HIF1A (0.55) | NFKB1NFKB2RELAKCNH2FNTA | |
| SCHEMBL15144388 | 0.80 | NFKB1 (0.47) | NFKB1NFKB2RELAKCNH2CYP19A1 | |
| SCHEMBL17549314 | 0.80 | NFKB1 (0.46) | NFKB1NFKB2RELAKCNH2CYP19A1 | |
| SCHEMBL9624281 | 0.80 | NR3C1 (0.43) | CYP19A1CYP3A4HIF1ANR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268400-B1 | STEROIDAL 17ALPHA-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGESTERONES | THE UPJOHN COMPANY (US) | 1992-04-29 | — | — | EP | claimed |