Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | FNTA | P49354 | 1/20 | 0.52 |
| ▸ | FNTB | P49356 | 1/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.45 |
| ▸ | AR | P10275 | 3/20 | 0.45 |
| ▸ | PGR | P06401 | 2/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP4 | P49662 | 1/20 | 0.40 |
| ▸ | CASP5 | P51878 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10413147 | 0.90 | NFKB1 (0.55) | NFKB1KCNH2NFKB2RELAFNTA | |
| SCHEMBL10625546 | 0.90 | NFKB1 (0.56) | NFKB1KCNH2NFKB2RELAFNTA | |
| SCHEMBL8859660 | 0.90 | NFKB1 (0.56) | NFKB1KCNH2NFKB2RELAFNTA | |
| SCHEMBL17066183 | 0.89 | NR3C1 (0.57) | NFKB1KCNH2NFKB2RELAFNTA | |
| SCHEMBL8859719 | 0.83 | NFKB1 (0.61) | NFKB1KCNH2NFKB2RELAFNTA | |
| SCHEMBL9623846 | 0.82 | NFKB1 (0.42) | NFKB1KCNH2NFKB2RELAFNTA | |
| SCHEMBL9470074 | 0.82 | NFKB1 (0.60) | NFKB1KCNH2NFKB2RELAFNTA | |
| SCHEMBL9623665 | 0.82 | NFKB1 (0.67) | NFKB1KCNH2NFKB2RELAFNTA | |
| SCHEMBL9623656 | 0.80 | NR3C1 (0.37) | NFKB1KCNH2NFKB2RELAFNTA | |
| SCHEMBL8940232 | 0.80 | NR3C1 (0.60) | NR3C1ARPGRNR3C2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268400-B1 | STEROIDAL 17ALPHA-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGESTERONES | THE UPJOHN COMPANY (US) | 1992-04-29 | — | — | EP | claimed |
| EP-0268400-B1 | STEROIDAL 17ALPHA-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGESTERONES | THE UPJOHN COMPANY (US) | 1992-04-29 | — | — | EP | disclosed |
| US-4977255-A | Steroidal 17α-silyl ethers and process to corticoids and progesterones | THE UPJOHN COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| US-4921638-A | 17β-cyano-9α,17α-dihydroxyandrost-4-en-3-one | THE UPJOHN COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| EP-0334875-A1 | STEROIDAL 17$g(a)-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGGESTERONES | THE UPJOHN COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |
| EP-0268400-A1 | Steroidal 17alpha-silyl ethers and process to corticoids and progesterones | THE UPJOHN COMPANY (US) | 1988-05-25 | — | — | EP | disclosed |
| WO-1988003534-A1 | STEROIDAL 17alpha-SILYL ETHERS AND PROCESS TO CORTICOIDS AND PROGGESTERONES | THE UPJOHN COMPANY (US) | 1988-05-19 | — | — | WO | disclosed |