Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624957 | 0.90 | HRH3 (0.40) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9624396 | 0.90 | MAPT (0.42) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10667609 | 0.87 | MAPT (0.42) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9625131 | 0.87 | SIGMAR1 (0.35) | SMPD1 | |
| SCHEMBL10664559 | 0.85 | MAPT (0.51) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9623564 | 0.84 | SMPD1 (0.36) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9624193 | 0.82 | SMPD1 (0.39) | MAPTSMPD1HTR1A | |
| SCHEMBL9624641 | 0.82 | MTNR1A (0.39) | MAPTALDH1A1KDM4ESMPD1 | |
| SCHEMBL9625049 | 0.82 | HTR1A (0.49) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10662506 | 0.81 | MAPT (0.51) | MAPTNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |