Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624380 | 0.90 | MAPT (0.39) | TDP1ALOX15MAPTHCN4CYP2D6 | |
| Hydrochloric Acid SCHEMBL9624724 | 0.89 | CYP3A4 (0.40) | ALOX15MAPTHCN4CYP2D6 | |
| SCHEMBL9624625 | 0.88 | ALDH1A1 (0.41) | TDP1ALOX15MAPT | |
| SCHEMBL9624248 | 0.85 | HDAC6 (0.35) | ALOX15MAPTHCN4 | |
| SCHEMBL9623778 | 0.85 | EDNRB (0.36) | ALOX15MAPTHCN4CYP2D6 | |
| SCHEMBL9623839 | 0.84 | ALDH1A1 (0.41) | TDP1ALOX15MAPT | |
| SCHEMBL9624809 | 0.84 | RAB9A (0.34) | MAPTHCN4CYP2D6 | |
| SCHEMBL9624353 | 0.83 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL9624772 | 0.82 | HCN4 (0.48) | PDE4DALOX15MAPTHCN4 | |
| SCHEMBL9623802 | 0.82 | GPR84 (0.34) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |