Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.33 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624311 | 0.91 | CYP2A6 (0.37) | MAPTCA2TP53HCN4CYP3A4 | |
| SCHEMBL9624291 | 0.90 | SMPD1 (0.36) | MAPTHCN4CYP3A4ALOX15HDAC6 | |
| SCHEMBL9624301 | 0.89 | MAPT (0.35) | MAPTTHRBUSP2CA2TP53 | |
| SCHEMBL9624336 | 0.89 | MAPT (0.44) | MAPTTHRBUSP2HCN4CYP3A4 | |
| SCHEMBL9624153 | 0.89 | MTNR1A (0.41) | MAPTHCN4CYP3A4ALOX15POLB | |
| SCHEMBL9625682 | 0.86 | PRKCB (0.35) | MAPTHDAC6LMNA | |
| SCHEMBL9624520 | 0.85 | PRKCB (0.34) | MAPTHDAC6LMNA | |
| SCHEMBL9624788 | 0.84 | SMPD1 (0.38) | MAPTHCN4CYP3A4ALOX15POLB | |
| SCHEMBL9625033 | 0.81 | ALDH1A1 (0.37) | MAPTTHRBUSP2CA2TP53 | |
| SCHEMBL9623726 | 0.81 | KMT2A (0.49) | MAPTLMNAHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |