Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 6/20 | 0.43 |
| ▸ | HTR1D | P28221 | 6/20 | 0.43 |
| ▸ | HTR1B | P28222 | 5/20 | 0.43 |
| ▸ | HTR5A | P47898 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624212 | 0.91 | SLC6A4 (0.48) | KMT2AMEN1LMNAMAPTHTT | |
| SCHEMBL9623773 | 0.90 | BCHE (0.46) | KMT2AMEN1LMNAMAPTHTT | |
| SCHEMBL9624496 | 0.89 | KMT2A (0.46) | KMT2AMEN1LMNAMAPTHTT | |
| SCHEMBL9624327 | 0.89 | MAPT (0.46) | KMT2AMEN1LMNAMAPTHTT | |
| SCHEMBL9624325 | 0.89 | HTR1A (0.52) | KMT2AMEN1LMNAMAPTHTR2A | |
| SCHEMBL9624504 | 0.85 | HTR2A (0.43) | MAPTHTR2ASLC6A4DRD2HTR6 | |
| SCHEMBL9624267 | 0.84 | HTR1D (0.57) | KMT2AMEN1LMNAMAPTHTR1D | |
| SCHEMBL9624653 | 0.81 | LMNA (0.46) | KMT2AMEN1LMNAMAPTHTT | |
| SCHEMBL9624529 | 0.81 | MAPT (0.37) | LMNAMAPTHTR5A | |
| SCHEMBL9624897 | 0.80 | HTR1A (0.52) | KMT2AMEN1LMNAMAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |