Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 8/20 | 0.40 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR1D | P28221 | 4/20 | 0.40 |
| ▸ | HTR1B | P28222 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624812 | 0.92 | SLC6A4 (0.45) | LMNAMEN1MAPTHTTKMT2A | |
| SCHEMBL9624308 | 0.90 | HTR1A (0.48) | LMNAMEN1MAPTKMT2ANPC1 | |
| SCHEMBL9623716 | 0.90 | BCHE (0.43) | MEN1MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL9624930 | 0.86 | MAPT (0.42) | LMNAMEN1MAPTHTTKMT2A | |
| SCHEMBL9624696 | 0.85 | HTR1D (0.53) | MEN1MAPTKMT2AHTR1DSLC6A4 | |
| SCHEMBL9624815 | 0.85 | KDM4E (0.45) | MAPTALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL9625033 | 0.83 | ALDH1A1 (0.37) | LMNAMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL9623726 | 0.81 | KMT2A (0.49) | LMNAMEN1MAPTHTTKMT2A | |
| SCHEMBL9624945 | 0.78 | MAPT (0.37) | MAPTALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL9624709 | 0.78 | MAPT (0.37) | MAPTALDH1A1HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |