Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624502 | 0.88 | HCN4 (0.43) | MEN1KMT2AMAPTHCN4CYP3A4 | |
| SCHEMBL9624374 | 0.87 | ALDH1A1 (0.35) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL9624203 | 0.78 | CYP2C9 (0.35) | KDM4EALDH1A1CYP2C9CYP2C19HDAC6 | |
| SCHEMBL9625527 | 0.78 | L3MBTL1 (0.38) | ALDH1A1LMNAHDAC6MAPTHCN4 | |
| SCHEMBL9624913 | 0.77 | MAPT (0.35) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL9624372 | 0.77 | TERT (0.46) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9624431 | 0.77 | HDAC6 (0.33) | KDM4EALDH1A1HDAC6MAPTHCN4 | |
| SCHEMBL9624873 | 0.77 | HDAC6 (0.35) | KDM4EMEN1ALDH1A1KMT2AHDAC6 | |
| SCHEMBL10400967 | 0.77 | KDM4E (0.34) | KDM4EALDH1A1LMNACYP2D6CYP2C19 | |
| SCHEMBL9624933 | 0.76 | HDAC6 (0.38) | KDM4EALDH1A1HDAC6MAPTHCN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |