Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR1E | P28566 | 1/20 | 0.47 |
| ▸ | HTR1F | P30939 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624930 | 0.92 | MAPT (0.42) | HTR1AHTR2AHTR6HTR3EHTR3B | |
| SCHEMBL9624987 | 0.91 | SLC6A4 (0.49) | HTR1AKMT2AMAPTMEN1LMNA | |
| SCHEMBL9624614 | 0.91 | HTR1D (0.51) | HTR6HTR1DKMT2AMAPTMEN1 | |
| SCHEMBL9624308 | 0.88 | HTR1A (0.48) | HTR1AHTR2AHTR6HTR3EHTR3B | |
| SCHEMBL9624855 | 0.84 | HCN4 (0.44) | HTR1AMTNR1AMTNR1BMAPTSLC6A4 | |
| SCHEMBL9624550 | 0.84 | HTR6 (0.42) | HTR2AHTR6HTR4MAPTSMN1; SMN2 | |
| SCHEMBL9623770 | 0.82 | MAPT (0.42) | HTR1AKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL9624225 | 0.82 | HCN4 (0.44) | HTR1AMAPTSLC6A4HCN4 | |
| SCHEMBL10649533 | 0.82 | HCN4 (0.62) | HTR1AHTR2AHTR6HTR3EHTR3B | |
| SCHEMBL9624897 | 0.82 | HTR1A (0.52) | HTR1AHTR2AHTR6HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |