Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624754 | 0.91 | HTR1A (0.47) | SLC6A4HTR1AMAPTHCN4MEN1 | |
| SCHEMBL9624930 | 0.91 | MAPT (0.42) | SLC6A4SLC6A2SLC6A3HTR1AMAPT | |
| SCHEMBL9624812 | 0.85 | SLC6A4 (0.45) | SLC6A4SLC6A2SLC6A3HTR1AMAPT | |
| SCHEMBL9624614 | 0.85 | HTR1D (0.51) | SLC6A4MAPTHCN4CNR2MEN1 | |
| SCHEMBL9623635 | 0.84 | HCN4 (0.44) | SLC6A4SLC6A2SLC6A3HTR1AMAPT | |
| SCHEMBL9624550 | 0.83 | HTR6 (0.42) | MAPTHCN4CYP3A4ALOX15CNR2 | |
| SCHEMBL10645698 | 0.82 | HCN4 (0.61) | SLC6A4SLC6A2SLC6A3HTR1AMAPT | |
| SCHEMBL9624469 | 0.82 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3HTR1AMAPT | |
| SCHEMBL9624308 | 0.79 | HTR1A (0.48) | SLC6A4HTR1AMAPTMEN1LMNA | |
| SCHEMBL9624011 | 0.78 | HCN4 (0.46) | SLC6A4HTR1AMAPTHCN4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |