Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 3/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 5/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624267 | 0.90 | HTR1D (0.57) | HTR1DTRPM8SLC6A4MAPTKDM4E | |
| SCHEMBL9624534 | 0.89 | HTR1D (0.55) | HTR1DTRPM8SLC6A4MAPTKDM4E | |
| SCHEMBL9625049 | 0.88 | HTR1A (0.49) | HTR1DSLC6A4MAPTHTR6MEN1 | |
| SCHEMBL9624748 | 0.86 | BCHE (0.44) | HTR1DSLC6A4MAPTHTR6MEN1 | |
| SCHEMBL9624496 | 0.84 | KMT2A (0.46) | HTR1DSLC6A4MAPTHTR6MEN1 | |
| SCHEMBL9625146 | 0.83 | SLC6A4 (0.46) | HTR1DTRPM8SLC6A4HTR6KMT2A | |
| SCHEMBL9215781 | 0.80 | HTR1D (0.48) | HTR1DTRPM8SLC6A4MAPTKDM4E | |
| SCHEMBL9624696 | 0.79 | HTR1D (0.53) | HTR1DTRPM8SLC6A4MAPTKDM4E | |
| SCHEMBL9624802 | 0.78 | DRD2 (0.40) | HTR1DMAPTHTR6KMT2ASMN1; SMN2 | |
| SCHEMBL9624614 | 0.78 | HTR1D (0.51) | HTR1DTRPM8SLC6A4MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |
| EP-0269968-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-06-08 | — | — | EP | disclosed |